Nucleic Acid Technology

Smarter RNA, Smartly Engineered

Rational nucleic acid design and advanced development technologies for next-generation RNA programs
Crystal NAX integrates AI models for sequence design with advanced nucleic acid engineering to enable high-performance RNA constructs. Our platform combines AI-assisted RNA and DNA design, cell-free high-throughput synthesis, and precision process optimization to support rapid iteration and informed decision-making.

We deliver high-quality mRNA and self-amplifying RNA (saRNA) with a strong emphasis on impurity control and byproduct reduction, ensuring consistency and functional performance. In parallel, our advanced sgRNA synthesis technologies support genome editing and CRISPR applications with high fidelity, reproducibility, and scalability.

RNA Smart Design

  • AI-assisted sequence modeling to optimize expression efficiency, stability, and translational performance
  • Rational design strategies informed by RNA structure, sequence features, and biological context
  • Multi-parameter optimization balancing potency, developability, and downstream compatibility
  • Rapid in silico iteration to guide experimental design and reduce trial-and-error
  • Support across multiple RNA modalities and application-specific design goals

DNA Clean Production

  • Cell-free DNA synthesis platforms enabling rapid, scalable, and high-throughput production
  • Minimization of host-derived contaminants and process-related impurities
  • Flexible template generation to support fast RNA prototyping and screening
  • High reproducibility and consistency across parallel DNA constructs
  • Designed for speed, quality, and seamless integration into RNA workflows

mRNA Multi-Smart Synthesis

  • Fast, streamlined mRNA synthesis workflows enabling rapid turnaround
  • High-throughput production with flexible scaling for research and preclinical needs
  • Advanced impurity control strategies achieving extremely low byproduct levels
  • Optimized IVT processes supporting diverse RNA sequences and formats
  • Comprehensive analytical technologies ensuring every quality attribute

sgRNA High-Fidelity Synthesis

  • Enzymatic synthesis technologies enabling high-fidelity sgRNA production
  • Support for long and complex guide RNA constructs
  • Tight control of sequence accuracy and structural integrity
  • High reproducibility for genome editing and CRISPR-based applications
  • Designed to meet demanding precision requirements in advanced research programs