Standard LNP Formulation
Validated lipid formulations and platform process.
Fast turnaround with efficient workflow.
Various choices on payloads modalities, scales & final formats.
Guaranteed quality with options for extra analysis.
Choose your formulation
| Lipid |
|---|
|
Commercial formulations |
|
• SM102-LNP |
|
• ALC0315-LNP |
|
• MC3-LNP |
|
• LP03-LNP |
|
NAX proprietary library |
| Payload |
|---|
|
• mRNA |
|
• saRNA |
|
• circRNA |
|
• mRNA + sgRNA |
|
• siRNA |
|
• DNA |
|
• Multi-payload |
| Process & Scale |
|---|
|
Microfluidics 0.5 – 20mg |
|
Traditional T mix 0.1 – 1mg |
|
TurbMix by NAX 1mg – 1g |
| QC testing |
|---|
|
• Encapsulation Efficiency: >85% |
|
• Size: 80 ± 20nm |
|
• PDI: <0.2* |
|
• Concentration: customized |
|
• pH: 7.4 ± 0.5 |
| Applications |
|---|
|
• In vitro cell studies • In vivo animal studies |
*Larger size payloads or multi-payloads might result in larger LNP size; PDI might result in <0.3 by traditional T mix.
Target LNP (tLNP) Formulation Services
Enhanced tissue and cell specificity for LNP delivery.
Various ligands and payloads available for selection.
Choose from several validated conjugation solutions.
Compatible with formulation ligands high-throughput screening.
Choose your service
| Formulation |
|---|
|
• Standard |
|
• NAX proprietary |
|
• Of the Client |
| Ligands |
|---|
|
• mRNA |
|
• Antibodies |
|
• Fragments |
|
• Peptides |
|
• Oligos |
| Conjugation |
|---|
|
• Thiol – Malenide |
|
• Click Chemistry |
|
• Micelle insertion |
|
• 0.1 – 5mg |
| QC testing |
|---|
|
• Encapsulation Efficiency: >85% |
|
• Size: 80 ± 20nm |
|
• PDI: <0.2* |
|
• Concentration: customized |
|
• pH: 7.4 ± 0.5 |
| Applications |
|---|
|
• In vitro cell studies |
|
• In vivo animal studies |
High-throughput LNP Formulation Screening
High-throughput formulation studies enable rapid exploration of lipid library, ligand library, formulation parameters and delivery performance. This approach supports efficient lead identification and optimization while minimizing development timelines.
Crystal NAX provides high-throughput LNP formulation study services combining automated mixing platforms with in vitro and in vivo evaluation.
- Parallel formulation generation and screening
- Rapid evaluation of lipid composition and formulation variables
- Data-driven ranking of formulation candidates
- Seamless processing for in vitro or in vivo validation
- Efficient use of material and development resources
LNP Process Development Study
High-throughput formulation studies enable rapid exploration of lipid library, ligand library, formulation parameters and delivery performance. This approach supports efficient lead identification and optimization while minimizing development timelines.
Crystal NAX provides high-throughput LNP formulation study services combining automated mixing platforms with in vitro and in vivo evaluation.
- Optimization through customized DOE studies for various mixing parameters, formulation conditions and process parameters
- Flexible scale-up strategies from mg up to 10g for preclinical needs
- Improved batch-to-batch consistency, robustness and product stability
- Process understanding to support informed development decisions
- Designed for adaptability, not fixed manufacturing constraints
