Key Advantages
- Each mRNA construct is fully optimized across CDS and UTR regions and screened from more than 20 sequence variants to identify candidates with the highest expression performance.
- mRNA is produced using strictly controlled IVT, oligo-dT purification, and tangential flow filtration (TFF) processes to minimize batch-to-batch variability and ensure reproducibility.
- Every batch is comprehensively characterized against IND-grade release specifications, including integrity, purity, and key quality attributes.
- Product performance is confirmed through in vitro expression and cell-based potency assays, ensuring that quality translates into functional outcomes.
- Each catalog mRNA has been extensively tested and validated by academic and industrial users across a wide range of research and development applications.
Our Promise
- Intelligent Sequence Optimization
- Highly Controlled Production Processes
- Quality-Driven Release Standards
- Functional Validation
- Broad Application Validation
Outstanding Results
Quality Specifications
| Quality Attributes | QC Method | Release Standard |
|---|---|---|
|
Appearance |
Visual Inspection |
Clear and free of foreign particles |
|
pH |
pH meter |
Target +/- 0.2 |
|
Content |
UV-Vis |
Target +/- 5% |
|
A260/280 |
UV-Vis |
1.8-2.2 |
|
Identity |
Sequencing |
Sequence fully match |
|
Integrity/Purity |
Capillary electrophoresis |
>90.0% |
|
Capping Efficiency |
LC-MS |
>95.0% |
|
dsRNA |
ELISA |
<0.1% |
|
Endotoxin |
LAL assay |
<5 EU/mg |
Trusted by clients
Executive Director
Korean Biotech Company
“Crystal NAX’s mRNA has demonstrated strong and consistent performance, which has led us to continue using their materials across our projects.
We also greatly appreciate the team’s professional, responsive, and customer-focused support.“
Outsourcing Manager
US Life Science Company
“NAX provides the highest-purity mRNA products supported by comprehensive analysis reports.
Their customer service is consistently prompt and helpful, and we consider them one of our most reliable suppliers.”
Chief Executive Officer
Boston Startup Company
“We had an outstanding experience working with Crystal NAX on mRNA generation and nanoparticle formulations. Their speed was exceptional, delivering high-quality materials on an aggressive timeline without any compromise in rigor or reproducibility.“
Frequently Requested Products
Product Description
EGFP mRNA (N(1)-Me-Pseudo UTP) is capable of expressing enhanced green fluorescent protein (EGFP) within cells following transfection. EGFP was originally extracted from the jellyfish (Aequorea Victoria), and is a commonly used reporter gene for direct detection in mammalian cell culture. It produces bright green fluorescence (Ex: 484 nm, Em: 509 nm).
This product can serve as a positive control for mRNA transfection, and further be used for screening and validation of delivery formulations or expression systems.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
FLuc mRNA (N(1)-Me-Pseudo UTP) is a firefly luciferase encoded mRNA sequence with modified UTP, which can express luciferase protein in cells after transfection. The protein was originally extracted from the firefly (Photinus pyralis). Luciferase can catalyze the oxidation of luciferin to produce oxyluciferin, emitting yellow-green bioluminescence (wavelength of 550-570 nm), and the light intensity directly reflects the expression level of luciferase.
This product can serve as a positive control for mRNA transfection, and be further used for screening and validation of delivery formulations or expression systems.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
Cas9 mRNA (N(1)-Me-Pseudo UTP) allows for the expression of a Streptococcus pyogenes SF370 Cas9 protein (CRISPR-associated protein 9), which is part of the CRISPR genome editing system, when transfected into cells. In the CRISPR system, when co-transfected with guide RNA (gRNA) targeting specific genomic loci, the Cas9 protein can cleave the targeted genes under the guidance of the gRNA.
This product is an in vitro transcribed Cas9 mRNA that can be transfected at any time and used for CRISPR/Cas9-mediated gene editing.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
mCherry mRNA (N(1)-Me-Pseudo UTP) is an mRNA molecule that allows for the expression of the red fluorescent protein mCherry when transfected into cells. mCherry is derived from the red fluorescent protein DsRed, which was originally isolated from the sea anemone (Discosoma). It is a monomeric fluorophore with a maximum absorption wavelength at 587 nm and a maximum emission wavelength at 610 nm. mCherry exhibits excellent photostability and is widely used for molecular labeling and cellular component localization in biological research.
This product can serve as a positive control for mRNA transfection, and further be used for screening and validation of delivery formulations or expression systems.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
CD19 CAR mRNA (N(1)-Me-Pseudo UTP) expresses anti-CD19 chimeric antigen receptor (CAR) in cells or in vivo. CD19 CAR is commonly used in CAR-T cell therapy. CD19 is widely present in most B cells and is also expressed in malignant tumors of B cell lineage. Therefore, CD19 can be used as a surface marker of B cells and a therapeutic target for B-cell malignancies.
CD19 CAR mRNA is prepared at higher concentration, convenient for T cell electroporation and LNP formulation.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
hEPO mRNA (N(1)-Me-Pseudo UTP) encodes human erythropoietin (hEPO), a hormone that controls red blood cell production or erythropoiesis. hEPO also plays a role in wound healing and the response of the brain to nerve injury. In addition to significantly promoting hematopoiesis, hEPO also has effects on angiogenesis, brain protection, kidney protection, heart protection, immune regulation, and the protection of the digestive and reproductive systems.
This product is an in vitro transcribed hEPO mRNA that can be transfected into cells and enables efficient expression. It can be used for experimental studies and validation of the regulatory functions of hEPO in various biological processes.
Need saRNA, circRNA version or a custom synthesis? Contact Us >>
Product Description
OVA mRNA (N(1)-Me-Pseudo UTP) produces ovalbumin in cells or in vivo. Ovalbumin is the main glycoprotein found in egg whites and commonly used as model antigen for immunization studies. OVA, as a T cell-dependent antigen, can activate specific T cell responses. It is used to study the activation, proliferation, and function of T cells, and the mechanism of antigen presentation in dendritic cells (DCs).
Need saRNA, circRNA version or a custom synthesis? Contact Us >>