Lipid Nanoparticles (LNP)

Intelligent LNP for Precision Delivery

Advanced formulation platforms enabling targeted, high-performance RNA delivery
Crystal NAX develops and applies advanced lipid nanoparticle technologies to enable efficient and programmable RNA delivery. Our LNP platform integrates rational lipid selection, high-throughput formulation screening, flexible mixing technologies and scales, and advanced surface functionalization strategies.

Designed for research and CMC development, our approach supports rapid optimization, customization, and data-driven delivery decisions across diverse applications.

Choose your smart lipid

  • Extensive proprietary lipid library supporting diverse RNA modalities
  • Lipid chemistries optimized for different organs, tissues, and cellular targets
  • Design strategies aligned with multiple routes of administration
  • Structure–function-driven lipid selection to guide formulation development
  • Flexible integration with downstream formulation and screening workflows

Formulate in high throughput

  • Integrated high-throughput LNP formulation and screening capabilities
  • Automated mixing and formulation workflows enabling rapid parallel testing
  • In vitro and in vivo validation platforms to assess delivery performance
  • Data-driven ranking and optimization of formulation candidates
  • Designed to accelerate lead selection and reduce development timelines

Various mixing technologies

  • Traditional T-mixing approaches for robust and established formulations
  • Multiple commercial microfluidic LNP systems for controlled nanoparticle assembly
  • Proprietary multichannel turbo-mixing technologies enabling high throughput and scalability
  • Flexible selection of mixing strategies based on formulation goals
  • Consistent particle quality across diverse formulation conditions

Surface conjugation & functionality

  • Extensive experience in LNP surface conjugation with antibodies, peptides, and aptamers
  • Support for diverse linker chemistries and conjugation strategies
  • Tailored surface functionalization to enable in-vivo target delivery applications
  • Seamless integration with high-throughput formulation screening platforms
  • Designed to rapidly evaluate targeting performance and structure–function relationships